Dr. Kenneth Chapman, M.D., M.Sc., F.R.C.P.C, F.A.C.P.
President, Inspiration Research Limited
Director, Asthma & Airway Centre, University Health Network
GSK-CIHR Researhch Chair in Respiratory Health Care Delivery
Dr. Kenneth Chapman is the founder and current president of Inspiration Research Limited. He is also the director of the Asthma and Airway Centre at the University Health Network. A graduate of the University of Toronto and a former member of the faculty at Case Western Reserve University, he is now a Professor of Medicine at the University of Toronto. He chaired Canada’s first Consensus Conference to establish Canadian guidelines for the management of COPD. Dr. Chapman has recently been named to the CIHR-GSK Research Chair in Respiratory Health Care Delivery.
Dr. Chapman is an internationally respected researcher in the field of asthma, chronic obstructive pulmonary disease (COPD) and airway diseases. His publications have appeared in the New England Journal of Medicine and the Lancet. The titles of more than 400 publications ranges "Emergency medical services for outdoor rock music festivals" to "The effect of posture on thoracoabdominal movements during progressive hyperoxic hypercapnia in conscious man". Dr. Chapman has been cited more than 6000 times.
Research Highlights: Asthma management strategies
It is now a standard of care that patients with unstable asthma are given a short course of oral steroids in hospital emergency rooms, walk-in clinics and offices to allow their safe discharge home. This strategy was first examined rigorously by Dr. Chapman and his colleagues who published their pivotal study in the New England Journal of Medicine *. This was followed by other studies examining the optimal strategies for managing asthma.
Optimizing asthma treatment outcomes lead inevitably to studies of patient education, compliance, and control assessment *. Doctor Chapman's work in patient education included establishing the Canadian Network for Respiratory Care, an organization that manages respiratory educator certification programs for Canada. He remains active executive member.
Chronic Obstructive Pulmonary Disease (COPD)
Dr. Chapman wrote Canada’s first guidelines for the management of COPD* and maintains a broad program of research in this area, addressing issues of diagnostic delay, epidemiology and non-invasive monitoring. He is a member of the CanCOLD consortium, a trans-Canadian program of study examining the natural history in a large population-based cohort of patients with COPD. He has addressed issues of gender bias in his work.
Alpha Antitrypsin Deficiency
Dr. Chapman follows a large number of patients with alpha1 antitrypsin deficiency* and is considered one of the world’s experts in this comparatively rare lung disease. His work reflects both the Canadian perspective (from the Canadian registry) and his collaboration with international colleagues.
Jane Duke BScN, RN, CCRP, CRE
Clinical Trials Coordinator
Jane Duke has worked at Inspiration Research Limited for over 14 years. She is responsible for overseeing overall operations in the clinic. Her experience is in the area of COPD, Asthma and Alpha 1 Antitrypsin Deficiency. She is a Certified Respiratory Educator with the Canadian Network for Respiratory Care. Prior to joining Inspiration, Jane had over 15 years of experience in conducting clinical trials in areas of organ transplant, cardiac care and respirology. She is a current member of SoCRA.
Shinead Callery RN
Clinical Trials Coordinator
Shinead Callery graduated as an RN from the Institute of Applied Health Sciences approximately 14 years ago. Her nursing career has mainly been in paediatric critical care (+8 years). She has also worked for the Ontario Poison Centre, in Diagnostic Imaging at HSC, Best Doctors, as a member advocate, and spent a small time working in a fertility clinic (mainly in the operating room). She is new to clinical research, but is looking forward to the adventures and challenges it will hold!
Sabah A RRT, RCPT (P)
Clinical Trials Coordinator
Sabah Amar is a Registered Respiratory Therapist graduating from the Michener Institute for Applied Health Sciences in 2015. She is also a Registered Cardio Pulmonary Technologist in the field of Pulmonary Technology. She has been working in the Pulmonary Function Lab at the University Health Network, Toronto General and Toronto Western Hospital. As a Clinical Trials Coordinator, Sabah is responsible for organizing and directing clinical research projects by keeping records of a clinical study including informed consent, screening interviews, medical records and all activities that are completed as per study requirements. She is also responsible for overseeing participant enrollment and ensuring compliance with protocols and objectives. With just a year of experience in research, Sabah will be working towards becoming a member of the Society of Clinical Research Associates and getting her Certified Respiratory Educator credentials.
Asthma Management Strategies
Chapman KR, Verbeek, PR, White JG, Rebuck AS. Effect of a short course oral prednisone in the prevention of early relapse after the emergency room treatment of acute asthma. N Engl J Med 1991; 324: 788-794
Chapman KR, Kesten S, Szalai JP. Regular versus as-needed use of inhaled salbutamol in asthma control. Lancet 1994; 1379-1382.
Hanania NA, Chapman KR, Sturtridge WC, Kesten S. Dose-related decrease in bone density among asthmatic patients treated with inhaled corticosteroids. J Allergy Clin Immunol 1995; 96: 571-579.
Chapman KR, Barnes NC, Greening AP, Jones PW, Pedersen S. Single maintenance and reliever therapy (SMART) of asthma: a critical appraisal. Thorax 2010; 65:747-752.
Fritscher LG, Marras TK, Bradi AC, Fritscher CC, Balter MS, Chapman KR. Non-tuberculous mycobacterial (NTM) infection as a cause of difficult-to-control asthma: a case control study. Chest 2010 [published online].
Hanania NA, Wittman R, Kesten S, Chapman KR. Medical personnnel's knowledge of and ability to use inhaling devices. Chest 1994; 105: 111-116.
Chapman KR, Ernst P, Grenville A, Dewland P, Zimmerman S. Control of asthma in Canada: failure to achieve guideline targets. Can Respir J 2001; 35A-40A.
Chapman KR, Boulet LP, Rea RM, Franssen E. Sub-optimal asthma control: prevalence, detection and consequences in primary practice. Eur Respir J 2008; 31: 320 – 325.
Chronic Obstructive Pulmonary Disease
Chapman KR, Bowie D, Hodder R, Julien M, Kesten S, Newhouse M, Pare PD. Canadian Thoracic Society Concensus Statement on the assessment and management of COPD. Can Med Assoc J 1992; 147: 421-428.
Kesten S. Chapman KR. Physician perceptions and management of COPD. Chest 1993; 104: 254-258.
Chapman KR, Tashkin DP, Pye DJ. Gender bias in the diagnosis of COPD. Chest 2001; 119: 1691 – 1695.
Chapman KR, Mannino DM, Soriano JB, Vermeire PA, Buist AS, Thun MJ, Connell C, Jemal A, Lee TA, Miravitlles M, Aldington S, Beasley R. Epidemiology and costs of chronic obstructive pulmonary disease. Eur Respir J 2006; 27: 188 – 207.
Alpha1 Antitrypsin Deficiency
Chapman KR, Stockley RA, Dawkins C, Wilkes MM, Navickis RJ. Augmentation therapy for α1 antitrypsin deficiency: a meta-analysis. J COPD 2009; 6: 177 – 184.